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A DNA Aptameric Ligand of Human Transferrin Receptor Generated by Cell-SELEX
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A DNA Aptameric Ligand of Human Transferrin Receptor Generated by Cell-SELEX
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Journal Article
A DNA Aptameric Ligand of Human Transferrin Receptor Generated by Cell-SELEX
2021
Overview
General cancer-targeted ligands that can deliver drugs to cells have been given considerable attention. In this paper, a high-affinity DNA aptamer (HG1) generally binding to human tumor cells was evolved by cell-SELEX, and was further optimized to have 35 deoxynucleotides (HG1-9). Aptamer HG1-9 could be taken up by live cells, and its target protein on a cell was identified to be human transferrin receptor (TfR). As a man-made ligand of TfR, aptamer HG1-9 was demonstrated to bind at the same site of human TfR as transferrin with comparable binding affinity, and was proved to cross the epithelium barrier through transferrin receptor-mediated transcytosis. These results suggest that aptamer HG1-9 holds potential as a promising ligand to develop general cancer-targeted diagnostics and therapeutics.
Publisher
MDPI AG,MDPI
Subject
