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Boron absorption imaging in rat lung colon adenocarcinoma metastases

by Clerici, A , Salvucci, O , Facoetti, A , Chiari, P , Bakeine, J , Nano, R , Altieri, S , Fossati, F , Ferrari, C , Bortolussi, S , Bruschi, P , Vittor, K

in Autoradiography / Boron / Cancer / Colon / Liquid nitrogen / Lungs / Metastasis / Nodules / Nuclear reactors / Physics / Rodents / Temporal distribution

2006

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Boron absorption imaging in rat lung colon adenocarcinoma metastases

by Clerici, A , Salvucci, O , Facoetti, A , Chiari, P , Bakeine, J , Nano, R , Altieri, S , Fossati, F , Ferrari, C , Bortolussi, S , Bruschi, P , Vittor, K

in Autoradiography / Boron / Cancer / Colon / Liquid nitrogen / Lungs / Metastasis / Nodules / Nuclear reactors / Physics / Rodents / Temporal distribution

2006

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Boron absorption imaging in rat lung colon adenocarcinoma metastases

by Clerici, A , Salvucci, O , Facoetti, A , Chiari, P , Bakeine, J , Nano, R , Altieri, S , Fossati, F , Ferrari, C , Bortolussi, S , Bruschi, P , Vittor, K

in Autoradiography / Boron / Cancer / Colon / Liquid nitrogen / Lungs / Metastasis / Nodules / Nuclear reactors / Physics / Rodents / Temporal distribution

2006

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Journal Article

Boron absorption imaging in rat lung colon adenocarcinoma metastases

Clerici, A,

Salvucci, O,

Facoetti, A,

Chiari, P,

Bakeine, J,

Nano, R,

Altieri, S,

Fossati, F,

Ferrari, C,

Bortolussi, S,

Bruschi, P,

Vittor, K

2006

Overview

Given the encouraging results from our previous work on the clinical application of BNCT on non-resectable, chemotherapy resistant liver metastases, we explore the possibility to extend our technique to lung metastases. A fundamental requirement for BNCT is achieving higher 10B concentrations in the metastases compared to those in healthy tissue. For this reason we developed a rat model with lung metastases in order to study the temporal distribution of 10B concentration in tissues and tumoral cells. Rats with induced lung metastases from colon adenocarcinoma were sacrificed two hours after intraperitoneal Boronphenylalanine infusion. The lungs were harvested, frozen in liquid nitrogen and subsequently histological sections underwent neutron autoradiography in the nuclear reactor Triga Mark II, University of Pavia. Our findings demonstrate higher Boron uptake in tumoral nodules compared to healthy lung parenchyma 2 hours after Boronphenylalanine infusion.

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Publisher

IOP Publishing

Subject

Autoradiography

/ Boron

/ Cancer

/ Colon

/ Liquid nitrogen

/ Lungs

/ Metastasis