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A prospective study of 68Ga-PSMA PET/CT imaging of HCC as diagnosed on conventional imaging to evaluate for potential 177Lu-PSMA therapy
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A prospective study of 68Ga-PSMA PET/CT imaging of HCC as diagnosed on conventional imaging to evaluate for potential 177Lu-PSMA therapy
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A prospective study of 68Ga-PSMA PET/CT imaging of HCC as diagnosed on conventional imaging to evaluate for potential 177Lu-PSMA therapy
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Journal Article
A prospective study of 68Ga-PSMA PET/CT imaging of HCC as diagnosed on conventional imaging to evaluate for potential 177Lu-PSMA therapy
2024
Overview
Objective
PSMA expression is seen in many solid tumours in addition to prostate cancer and several studies and case reports have shown PSMA expression and
68
Ga-PSMA imaging of hepatocellular carcinoma (HCC). Our prospective study evaluates the role of
68
Ga-PSMA in HCC patients and compares it to conventional imaging (CE-CT/MRI).
Methods
Patients with radiologically and/or histopathologically confirmed HCC were included and all had undergone serum alpha-fetoprotein (S.AFP) assessment as well as CE-CT/MRI prior to PSMA PET/CT. Acquired whole-body PET/CTs were analysed both visually and quantitatively by two experienced nuclear medicine physicians.
Results
Forty-one (41) patients (36 male; 5 female) with known HCC and a mean age of 53.9 ± 10.9 years underwent
68
Ga-PSMA PET/CT. All patients had lesions on conventional imaging but only 38/41 patients showed
68
Ga-PSMA uptake. Conventional imaging revealed 18 patients with single lesions, all of which were tracer avid. Twenty-three (23) of 41 patients had multifocal (> 2) hepatic lesions on CE-CT/MRI of which 3 patients showed no
68
Ga-PSMA uptake, 7 showed tracer uptake in a single lesion only and 13 patients had multifocal tracer avid lesions. There was no correlation observed between S. AFP level and tumour SUV
max
on
68
Ga-PSMA PET/CT.
Conclusion
68
Ga-PSMA PET/CT imaging of HCC may complement conventional imaging and identify patients for potential theranostic intervention.
