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Efficient and Practical Route for 3,5-Dichloro-4-(1,1,2,2-tetrafluoroethoxy)aniline: a Key Intermediate of Hexaflumuron
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Efficient and Practical Route for 3,5-Dichloro-4-(1,1,2,2-tetrafluoroethoxy)aniline: a Key Intermediate of Hexaflumuron
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Efficient and Practical Route for 3,5-Dichloro-4-(1,1,2,2-tetrafluoroethoxy)aniline: a Key Intermediate of Hexaflumuron
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Journal Article
Efficient and Practical Route for 3,5-Dichloro-4-(1,1,2,2-tetrafluoroethoxy)aniline: a Key Intermediate of Hexaflumuron
2023
Overview
An improved and practical route is reported here for accessing 3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)aniline (
1
), a key intermediate of hexaflumuron. The overall yield for the preparation of
1
is 74.0%, with a purity of 99.7%, after a one-pot process with catalytic hydrogenation and Bamberger rearrangement and a greener addition reaction in a continuous flow reactor. Compared with the original process route, the new synthetic route has the advantages of fewer reaction steps, higher overall yield, less process safety hazard and environmental impact.
Publisher
Pleiades Publishing,Springer Nature B.V
Subject
