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Novel hydroxyapatite nanoparticle-based antibiotic alternative to combat methicillin-resistant S. aureus: A mechanism by targeting the structural and functional stability of MRSA membrane protein
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Novel hydroxyapatite nanoparticle-based antibiotic alternative to combat methicillin-resistant S. aureus: A mechanism by targeting the structural and functional stability of MRSA membrane protein
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Journal Article
Novel hydroxyapatite nanoparticle-based antibiotic alternative to combat methicillin-resistant S. aureus: A mechanism by targeting the structural and functional stability of MRSA membrane protein
2023
Overview
In order to overcome the growing bacterial resistance, increasing effective and efficient utilization of antibiotics or the development of newer techniques against the infection is of utmost importance. Amongst the various therapeutic strategies, nanotechnology-based approaches are being explored to combat drug-resistant pathogens. Strategies leading to the degradation of cellular protein have opened up new avenues of research. In this study, we aimed to investigate the applicability of functionalized hydroxyapatite nanoparticles (HAp NPs) on the conformational stability of α-Enolase, a membrane protein of methicillin-resistant
S. aureus
(MRSA). Various shaped HAp NPs were synthesized and subsequently surface functionalized. α-Enolase was extracted and purified from MRSA strain and its interactions with un-functionalized and surface-functionalized HAp NPs of various morphologies were studied. This is the first comprehensive study to report the interaction of HAp NPs with Enolase which explores the effect on the functionality of Enolase after interaction with the nanoparticle.
Graphical abstract
Publisher
Springer International Publishing,Springer Nature B.V
Subject
