Journal Article

Changes in interhemispheric coherence after total corpus callosotomy: a scalp EEG study in children with non-lesional generalized epilepsy

Inoue, Takeshi, Kuki, Ichiro, Kunihiro, Noritsugu, Yindeedej, Vich, Fukuoka, Masataka, Goto, Takeo, Nishijima, Shugo, Okazaki, Shin, Uda, Takehiro, Nukui, Megumi, Umaba, Ryoko

2024

Overview

Purpose Coherence analysis in electroencephalography (EEG) allows measurement of the degree of consistency of amplitude between pairs of electrodes. Theoretically, disconnective epilepsy surgery should decrease coherence between corresponding areas. The study aimed to evaluate postoperative changes in interhemispheric coherence values after corpus callosotomy (CC). Methods Non-lesional, drug-resistant, generalized epilepsy patients who underwent total CC were retrospectively collected. To evaluate coherence, we divided the scalp interictal EEG into “baseline” and “discharge” states after excluding periods with artifacts. Interhemispheric coherence values were obtained between eight pairs of symmetrically opposite scalp electrodes in six different frequency bands. We analyzed both pre- and postoperative EEG sessions and calculated the percentage of difference (POD) in coherence values. Results We collected 13 patients and analyzed 2496 interhemispheric coherence values. Preoperative coherence values differed significantly between baseline and discharge states ( p  = 0.0003), but postoperative values did not ( p  = 0.11). For baseline state, coherence values were decreased after CC and median POD was − 22.3% ( p  < 0.0001). Delta frequency showed the most decreased POD (-44.3%, p  = 0.0009). Median POD was lowest in the Fp1-Fp2 pair of electrodes. For discharge state, coherence values were decreased after CC and median POD was − 24.7% ( p  < 0.0001). Delta frequency again showed the most decreased POD (-55.9%, p  = 0.0016). Median POD was lowest in the F7-F8 pair. Conclusion After total CC, interhemispheric coherence decreased significantly in both baseline and discharge states. The most decreased frequency band was the delta band, which may be used as a representative frequency band in future studies.

• Publisher: Springer Berlin Heidelberg,Springer Nature B.V
• Subject: Adolescent / Child / Child, Preschool / Corpus Callosum - physiopathology / Corpus Callosum - surgery / Drug Resistant Epilepsy - physiopathology / Drug Resistant Epilepsy - surgery / Electroencephalography - methods / Epilepsy, Generalized - physiopathology / Epilepsy, Generalized - surgery / Female / Humans / Male / Medicine / Medicine & Public Health / Neurosciences / Neurosurgery / Retrospective Studies / Scalp