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Antimicrobial utilization in very-low-birth-weight infants: association with probiotic use

by Bodani, Jaya , Beltempo, Marc , Masse, Edith , Lee, Shoo K , Lemyre, Brigitte , Lee, Kyong-Soon , Piedboeuf, Bruno , Barrington, Keith , St-Hilaire, Marie , Augustine, Sajit , Ethier, Guillaume , Fajardo, Carlos , Mehrem, Ayman Abou , Bizgu, Victoria , Fajardo, Carlos A , Toye, Jennifer , Louis, Deepak , Shah, Prakesh S , Makary, Hala , Monterrosa, Luis , Claveau, Martine , Ting, Joseph Y , Ojah, Cecil , Kanungo, Jaideep , Drolet, Christine , Bertelle, Valérie , Kajetanowicz, Andrzej , Da Silva, Orlando , Ng, Eugene , Afifi, Jehier , Yoon, Eugene W , Strueby, Lannae , Cieslak, Zenon , Alvaro, Ruben , Khurshid, Faiza , Emberley, Julie , Sherlock, Rebecca , Canning, Roderick , Daboval, Thierry , Wong, Jonathan , Seshia, Mary , Lapointe, Anie , Bertelle, Valerie , Mukerji, Amit

in Antibiotics / Antiinfectives and antibacterials / Antimicrobial agents / Babies / Birth / Birth weight / Generalized linear models / Gestational age / Hospitals / Infants / Intensive care / Intensive care units / Low birth weight / Microbiota / Mortality / Necrotizing enterocolitis / Neonatal care / Neonates / Obstetrics / Pediatrics / Probiotics / Sepsis / Utilization / Variables

2022

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Antimicrobial utilization in very-low-birth-weight infants: association with probiotic use

2022

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2022

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Journal Article

Antimicrobial utilization in very-low-birth-weight infants: association with probiotic use

Bodani, Jaya,

Beltempo, Marc,

Masse, Edith,

Lee, Shoo K,

Lemyre, Brigitte,

Lee, Kyong-Soon,

Piedboeuf, Bruno,

Barrington, Keith,

St-Hilaire, Marie,

Augustine, Sajit,

Ethier, Guillaume,

Fajardo, Carlos,

Mehrem, Ayman Abou,

Bizgu, Victoria,

Fajardo, Carlos A,

Toye, Jennifer,

Louis, Deepak,

Shah, Prakesh S,

Makary, Hala,

Monterrosa, Luis,

Claveau, Martine,

Ting, Joseph Y,

Ojah, Cecil,

Kanungo, Jaideep,

Drolet, Christine,

Bertelle, Valérie,

Kajetanowicz, Andrzej,

Da Silva, Orlando,

Ng, Eugene,

Afifi, Jehier,

Yoon, Eugene W,

Strueby, Lannae,

Cieslak, Zenon,

Alvaro, Ruben,

Khurshid, Faiza,

Emberley, Julie,

Sherlock, Rebecca,

Canning, Roderick,

Daboval, Thierry,

Wong, Jonathan,

Seshia, Mary,

Lapointe, Anie,

Bertelle, Valerie,

Mukerji, Amit

2022

Overview

ObjectiveTo examine the association between probiotic use and antimicrobial utilization.Study designWe retrospectively evaluated very-low-birth-weight (VLBW) infants admitted to tertiary neonatal intensive care units in Canada between 2014 and 2019. Our outcome was antimicrobial utilization rate (AUR) defined as number of days of antimicrobial exposure per 1000 patient-days.ResultOf 16,223 eligible infants, 7279 (45%) received probiotics. Probiotic use rate increased from 10% in 2014 to 68% in 2019. The AUR was significantly lower in infants who received probiotics vs those who did not (107 vs 129 per 1000 patient-days, aRR = 0.89, 95% CI [0.81, 0.98]). Among 13,305 infants without culture-proven sepsis or necrotizing enterocolitis ≥Stage 2, 5931 (45%) received probiotics. Median AUR was significantly lower in the probiotic vs the no-probiotic group (78 vs 97 per 1000 patient-days, aRR = 0.85, 95% CI [0.74, 0.97]).ConclusionProbiotic use was associated with a significant reduction in AUR among VLBW infants.

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Publisher

Nature Publishing Group

Subject

Antibiotics

/ Antiinfectives and antibacterials

/ Antimicrobial agents

/ Babies

/ Birth

/ Birth weight

/ Generalized linear models