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The Dark Side of IFN-γ: Its Role in Promoting Cancer Immunoevasion
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Journal Article
The Dark Side of IFN-γ: Its Role in Promoting Cancer Immunoevasion
2017
Overview
Interferon-γ (IFN-γ) is a pleiotropic cytokine that has long been praised as an important effector molecule of anti-tumor immunity, capable of suppressing tumor growth through various mechanisms. On the contrary to such a bright side of IFN-γ, it has also been involved in promoting an outgrowth of tumor cells with immunoevasive phenotype suggesting an existence of a dark “tumor-promoting” side effect of IFN-γ. In this review, we will summarize this multi-functional role of IFN-γ in tumor context, how it promotes changes in tumor phenotype towards increased fitness for growth in immunocompetent host. Furthermore, we summarize how IFN-γ is involved in homeostatic or cancer-triggered mechanisms to establish an immunosuppressive tumor microenvironment.
Publisher
MDPI AG,MDPI
Subject
/ Animals
/ Antigens
/ Gene Expression Regulation, Neoplastic
/ Genes
/ Humans
/ Interferon-gamma - immunology
/ Killer Cells, Natural - immunology
/ Killer Cells, Natural - pathology
/ Kinases
/ Melanoma
/ Mice
/ Neoplasm Proteins - genetics
/ Neoplasm Proteins - immunology
/ Review
/ T-Lymphocytes, Cytotoxic - immunology
/ T-Lymphocytes, Cytotoxic - pathology
/ T-Lymphocytes, Regulatory - immunology
/ T-Lymphocytes, Regulatory - pathology
/ Tumors
