Asset Details
Do you wish to reserve the book?
Antiurolithic activity of vanillin in ethylene glycol-induced hyperoxaluric rat model
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Antiurolithic activity of vanillin in ethylene glycol-induced hyperoxaluric rat model
Do you wish to request the book?
Antiurolithic activity of vanillin in ethylene glycol-induced hyperoxaluric rat model
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Antiurolithic activity of vanillin in ethylene glycol-induced hyperoxaluric rat model
2025
Overview
Vanillin, a natural compound derived from vanilla beans, exhibits antioxidant and anti-inflammatory properties, which may contribute to the prevention and treatment of renal stones. Therefore, this study is aimed to investigate the potential antiurolithic effect of vanillin in male hyperoxaluric Wistar rats. Computational molecular docking studies were used to investigate the interaction process and verify vanillin’s role in the prevention of kidney stones containing calcium oxalate. Software tools were utilized to analyze the drug ligands’ additional molecular characteristics, absorption, distribution, metabolism, and excretion (ADME), and toxicity. Urinary crystals were induced in rats by adding 0.75% ethylene glycol (EG) in drinking water for 3 weeks, along with 1% ammonium chloride (AC) during the initial three days. Molecular docking analysis revealed strong binding interactions of vanillin with Human CTP: Phosphoethanolamine Cytidylyltransferase (PDB ID: 3ELB) at the C5P binding site, with a binding affinity of -7.6 kcal/mol, suggesting a potential molecular basis for its antiurolithic activity. In vivo study showed that vanillin treatment dose dependently (30, 100 and 300 mg/kg body weight) reduced hyperoxaluria, hypercalciuria and crystal counts in kidneys of hyperoxaluric rats. The current results of our study suggest that vanillin possesses potential antiurolithic activity, showing enhanced therapeutic effects in urolithiasis, which could be a safe, effective and non-invasive option in modern medicine for the management of urinary stones.
Publisher
Springer Berlin Heidelberg,Springer Nature B.V
Subject
/ Benzaldehydes - pharmacology
/ Benzaldehydes - therapeutic use
/ Crystals
/ Dose-Response Relationship, Drug
/ Humans
/ Hyperoxaluria - chemically induced
/ Hyperoxaluria - drug therapy
/ Kidney Calculi - prevention & control
/ Kidneys
/ Male
/ Medicine
/ Molecular Docking Simulation
/ Proteins
/ Rats
/ Software
/ Toxicity
/ Urine
/ Urology
