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Linguistics-based formalization of the antibody language as a basis for antibody language models
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Linguistics-based formalization of the antibody language as a basis for antibody language models
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Journal Article
Linguistics-based formalization of the antibody language as a basis for antibody language models
2024
Overview
Apparent parallels between natural language and antibody sequences have led to a surge in deep language models applied to antibody sequences for predicting cognate antigen recognition. However, a linguistic formal definition of antibody language does not exist, and insight into how antibody language models capture antibody-specific binding features remains largely uninterpretable. Here we describe how a linguistic formalization of the antibody language, by characterizing its tokens and grammar, could address current challenges in antibody language model rule mining.
Publisher
Nature Publishing Group
Subject
