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PD-L2 expression in senescent cancer cells limits tumor clearance after chemotherapy
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PD-L2 expression in senescent cancer cells limits tumor clearance after chemotherapy
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Journal Article
PD-L2 expression in senescent cancer cells limits tumor clearance after chemotherapy
2024
Overview
Senescent cancer cells, which are characteristically present in tumors after genotoxic therapies, upregulate the immune checkpoint ligand programmed cell death 1 ligand 2 (PD-L2). We show that genetic or pharmacological ablation of PD-L2 prevents the accumulation of intratumoral senescent cells, reducing the recruitment of immunosuppressive myeloid cells and facilitating tumor clearance by T cells.
