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The Fine Structure of Intestine and Liver in Irradiated Mice during Fat Absorption
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The Fine Structure of Intestine and Liver in Irradiated Mice during Fat Absorption
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Journal Article
The Fine Structure of Intestine and Liver in Irradiated Mice during Fat Absorption
1972
Overview
C57Br/cdj mice were exposed to 1500 R whole-body X irradiation and sacrificed 1, 2, 3, 3.5, and 4 days postirradiation. Thirty minutes prior to sacrifice each mouse received 0.2 ml of safflower $\\text{oil-}{}^{3}{\\rm H}\\text{-palmitic}$ acid. Specimens of ileum, jejunum, and liver were examined with light and electron microscopes. Through 2 days postexposure, absorption and transport of lipid in both ileum and jejunum were essentially normal and liver glycogen and lipid content were stable. Beginning on day 3 ileal function began to fail rapidly but the jejunum functioned near normal. On day 3.5 jejunal absorption declined somewhat and hepatocytes were virtually depleted of glycogen and of intracellular lipid. Changes in absorption paralleled subcellular changes in epithelial cells, e.g., mitochondria were abnormal in appearance and reduced in number, ribosomes were depleted and only remnants of endoplasmic reticulum and Golgi membranes remained. The cellular effects observed are in accord with the time of onset of inhibition of protein synthesis in epithelial cells exposed to X rays, suggesting that irradiated cells lost the ability to synthesize the protein necessary to maintain the intracellular enzyme systems required for normal metabolism and the exportable protein components of chylomicrons. Failure of protein synthesis is attributed to inhibition of ribonucleoprotein synthesis or of ribosomal assembly rather than a direct effect on existing ribosomes.
Publisher
Academic Press, Inc
Subject
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