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β-Adrenergic Receptor Involvement in 6-Hydroxydopamine-Induced Supersensitivity in Rat Cerebral Cortex
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β-Adrenergic Receptor Involvement in 6-Hydroxydopamine-Induced Supersensitivity in Rat Cerebral Cortex
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Journal Article
β-Adrenergic Receptor Involvement in 6-Hydroxydopamine-Induced Supersensitivity in Rat Cerebral Cortex
1976
Overview
The intraventricular administration of 6-hydroxydopamine, a procedure which destroys noradrenergic nerve terminals in the central nervous system, caused an increase in the density of β-adrenergic receptors in rat cerebral cortex, without affecting their affinity for isoproterenol. The results suggest that changes in the density of adrenergic receptors are involved in 6-hydroxydopamine-induced supersensitivity at central noradrenergic synapses.
Publisher
American Association for the Advancement of Science
Subject
Adrenergic beta-Antagonists - metabolism
/ Animals
/ Cerebral Cortex - drug effects
/ Cerebrum
/ Density
/ Dose-Response Relationship, Drug
/ Fossils
/ Horses
/ Hydroxydopamines - pharmacology
/ Isoproterenol - pharmacology
/ Male
/ Nerves
/ Rats
/ Receptors, Adrenergic - drug effects
