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Apoptotic epithelial cells control the abundance of Treg cells at barrier surfaces
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Journal Article
Apoptotic epithelial cells control the abundance of Treg cells at barrier surfaces
2016
Overview
Epithelia continually undergo apoptosis, but the physiological importance of this is unclear. Shibuya and colleagues show that apoptotic epithelial cells bind the glycoprotein CD300a on a dendritic cell subset at barrier surfaces and this negatively regulates commensal-driven T
reg
cell proliferation.
Epithelial tissues continually undergo apoptosis. Commensal organisms that inhabit the epithelium influence tissue homeostasis, in which regulatory T cells (T
reg
cells) have a central role. However, the physiological importance of epithelial cell apoptosis and how the number of T
reg
cells is regulated are both incompletely understood. Here we found that apoptotic epithelial cells negatively regulated the commensal-stimulated proliferation of T
reg
cells. Gut commensals stimulated CX3CR1
+
CD103
−
CD11b
+
dendritic cells (DCs) to produce interferon-β (IFN-β), which augmented the proliferation of T
reg
cells in the intestine. Conversely, phosphatidylserine exposed on apoptotic epithelial cells suppressed IFN-β production by the DCs via inhibitory signaling mediated by the cell-surface glycoprotein CD300a and thus suppressed T
reg
cell proliferation. Our findings reveal a regulatory role for apoptotic epithelial cells in maintaining the number of T
reg
cell and tissue homeostasis.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ 13/31
/ 13/51
/ 13/89
/ 14/19
/ 38/61
/ 38/77
/ 64/60
/ Animals
/ Colitis - chemically induced
/ Dendritic Cells - immunology
/ Dermatitis, Allergic Contact - etiology
/ Dermatitis, Allergic Contact - immunology
/ Dermatitis, Allergic Contact - pathology
/ Epithelial Cells - immunology
/ Gastrointestinal Microbiome - immunology
/ Interferon-beta - immunology
/ Intestinal Mucosa - cytology
/ Intestinal Mucosa - immunology
/ Langerhans Cells - immunology
/ Mice
/ Real-Time Polymerase Chain Reaction
/ Receptors, Immunologic - genetics
/ Respiratory Mucosa - cytology
/ Respiratory Mucosa - immunology
