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Problematic clinical trials in thyroid cancer: the issue of papillary carcinoma and observational approaches
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Problematic clinical trials in thyroid cancer: the issue of papillary carcinoma and observational approaches
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Journal Article
Problematic clinical trials in thyroid cancer: the issue of papillary carcinoma and observational approaches
2017
Overview
We describe the clinical ethics problem of American thyroid cancer patients being offered 'observation' instead of the USA standard of care with questionable informed consent. This problem arose because some American practitioners misinterpreted 1990s Japanese studies. American proponents of these studies failed to recognize major differences in ethical oversight between Japanese and US clinical research, misrepresenting these studies as justifying clinical practices for higher risk patients that were not supported by data. The current professional environment in American thyroid cancer management is sufficiently problematic that consideration should be made, for patients who have inadvertently consented to nonevidence-based treatments, to be recontacted and provided an opportunity to revisit their care plans or seek second opinions regarding an observational approach.
