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Hot topics in epigenetic regulation of cancer self-renewal for pancreatic tumors: future trends
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Hot topics in epigenetic regulation of cancer self-renewal for pancreatic tumors: future trends
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Journal Article
Hot topics in epigenetic regulation of cancer self-renewal for pancreatic tumors: future trends
2019
Overview
Since THOR was shown to associate with TERT expression (3), our group investigated TERT expression in pancreatic cancer and found a positive correlation with THOR methylation levels. The authors (12) suggested that ofCS could play a key role in tumor-cell motility through integrin signaling pathways, and therefore supports the metastatic potential of cancer cells (13). Testing a wide range of cells and tissues, the authors found that the recombinant VAR2CSA protein binds >95% of cancer cell lines and tissues of epithelial, mesenchymal and hematopoietic origin, with very limited binding to noncancerous cells or normal tissue (besides placental tissue), which it could improve its role as tool to broadly and efficiently capture rare cancer cells in complex blood samples (10,12). [...]more robust and well-designed clinical trials are important to assess the role of all these aforementioned biomarkers in the pancreatic cancer framework.
Publisher
Future Medicine Ltd
Subject
/ Cell Self Renewal - genetics
/ Gene Expression Regulation, Neoplastic
/ Genes
/ Humans
/ Malaria
/ Neoplastic Cells, Circulating
/ Neoplastic Stem Cells - metabolism
/ Neoplastic Stem Cells - pathology
/ Pancreatic Neoplasms - genetics
/ Pancreatic Neoplasms - pathology
/ Patients
/ Proteins
/ THOR
/ Tumors
