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Central and Local Modulators of Reproduction and Fertility: An Update
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Central and Local Modulators of Reproduction and Fertility: An Update
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Journal Article
Central and Local Modulators of Reproduction and Fertility: An Update
2022
Overview
According to the World Health Organization, “Infertility affects millions of people of reproductive age worldwide—and has an impact on their families and communities. [...]the need to broaden the knowledge on the modulators of reproduction and fertility in both sexes, in order to expand the plethora of possible markers and therapeutic targets in the clinical setting. Non-genomic and genomic pathways of oestrogen signalling, and molecular mechanisms occurring through the alteration of mitogen-activated protein kinase and SRY-box transcription factor 9 in somatic cells have been reported; both are responsible for cell fate decision, the suppression of testis genes and the activation of ovarian genes. [...]there is a need for additional studies in the intratesticular characterisation of this deacethylase.
