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The roles of K+ channels in cancer
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Journal Article
The roles of K+ channels in cancer
2014
Overview
Key Points
Ion transport molecules are involved in many physiological and pathological processes.
Among ion transporters, potassium channels show the highest variability and the most frequently altered expression in many tumour types.
Cell cycle and proliferation, cell migration, invasion and apoptosis are all processes that can be modified by the expression of potassium channels.
Permeation-dependent and permeation-independent mechanisms contribute to the roles of potassium channels in oncological processes.
The experience gained with pharmacological manipulation of potassium channels in other pathologies might facilitate the use of potassium channels as cancer targets.
Potassium channels are transmembrane proteins that selectively facilitate the flow of potassium ions down an electrochemical gradient. Their roles in cell proliferation, angiogenesis and cell migration have only recently been assessed. Thus, the potential importance of these channels for tumour biology is only now becoming evident.
Potassium channels are transmembrane proteins that selectively facilitate the flow of potassium ions down an electrochemical gradient. These molecules have been studied in great detail in the context of cell excitability, but their roles in less cell type-specific functions, such as cell proliferation, angiogenesis or cell migration, have only recently been assessed. Moreover, the importance of these channels for tumour biology has become evident. This, coupled with the fact that they are accessible proteins and that their pharmacology is well characterized, has increased the interest in investigating potassium channels as therapeutic targets in cancer patients.
Publisher
Nature Publishing Group UK,Nature Publishing Group
