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Biodistribution and radiation dosimetry of 82Rb at rest and under adenosine stress in the paediatric population
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Biodistribution and radiation dosimetry of 82Rb at rest and under adenosine stress in the paediatric population
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Biodistribution and radiation dosimetry of 82Rb at rest and under adenosine stress in the paediatric population
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Journal Article
Biodistribution and radiation dosimetry of 82Rb at rest and under adenosine stress in the paediatric population
2025
Overview
Background
We aimed to estimate
82
Rb paediatric dosimetry based on adult biokinetic and prospectively acquired paediatric biokinetic data. Organ absorbed doses (OAD) and effective doses (E) were estimated using ICRP-103 based OLINDA/EXM.2.1 software. We extrapolated paediatric OAD and E from existing adult biokinetic data (OAD
p, Ab
and E
p, Ab
respectively).
82
Rb EANM paediatric dosage card (PDC) cluster and the recommended administered activity were determined. Ten paediatric participants (M: F 7:3; mean age 8.8 ± 6.6y) underwent prospectively 3D-SiPM
82
Rb PET/CT. Using PMOD software, source organs volumes were delineated to obtain source organ time activity curves and participant specific organ masses based on PET/CT data. Subject specific OAD (OAD
p
and E
p
respectively) were derived from original paediatric data.
Results
82
Rb was assigned to the EANM PDC B-Cluster. Estimated ranges for E
p, Ab
resp. E
p
were 2.19E-02 ̶ 1.15E-03 resp. 9.62E-03 ̶ 1.04E-03 mSv/MBq. E
p, Ab
resp. E
p
with 10 MBq/kg and 5MBq/kg after a single
82
Rb infusion was between 0.5 and 0.7 mSv resp. 0.4–0.8 mSv and 0.2–0.4 mSv. The most irradiated organs were the kidneys and the heart wall in infant and newborn group, followed by heart wall in the other age groups, hence, the small intestine, pancreas, lungs, adrenals, and rest of the gastrointestinal tract.
82
Rb PET/CT was safe and well-tolerated by all participants.
Conclusions
We firstly provide original dosimetry data for the use of
82
Rb PET/CT in the paediatric population, showing reasonably low radiation exposure, and confirming safety and tolerability of
82
Rb PET/CT in this population.
