Asset Details
Do you wish to reserve the book?
Lanthanum chloride impairs spatial learning and memory and downregulates NF-κB signalling pathway in rats
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Lanthanum chloride impairs spatial learning and memory and downregulates NF-κB signalling pathway in rats
Do you wish to request the book?
Lanthanum chloride impairs spatial learning and memory and downregulates NF-κB signalling pathway in rats
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Lanthanum chloride impairs spatial learning and memory and downregulates NF-κB signalling pathway in rats
2013
Overview
Exposure to rare earth elements (REEs) is known to impair intelligence in children and cause neurobehavioral abnormalities in animals. However, the mechanisms underlying these phenomena are not clear. Lanthanum is often used to study the effects of REEs. The aim of this study was to investigate the influence of lanthanum chloride (LaCl
3
) on spatial learning and memory and a possible underlying mechanism involving nuclear factor-kappa B (NF-κB) signalling pathway expression in the hippocampus. The rats were exposed to 0, 0.25, 0.50 or 1.00 % LaCl
3
in drinking water during pregnancy and lactation (i.e. while feeding their offspring). After weaning, young rats continued to receive 0, 0.25, 0.50 and 1.00 % LaCl
3
in the drinking water for 1 month. LaCl
3
exposure impaired the spatial learning and memory of young rats and significantly decreased the expression of phosphorylated IκB kinase complex, phosphorylated IκBα, NF-κB, c-fos, c-jun and brain-derived neurotrophic factor in the hippocampus. These results indicate that LaCl
3
exposure impairs spatial learning and memory in rats by inhibiting NF-κB signalling pathway.
Publisher
Springer Berlin Heidelberg
Subject
/ Biomedical and Life Sciences
/ Brain-Derived Neurotrophic Factor - biosynthesis
/ Cerebral Cortex - metabolism
/ Down-Regulation - drug effects
/ Electrophoretic Mobility Shift Assay
/ Hippocampus - ultrastructure
/ I-kappa B Kinase - metabolism
/ Maze Learning - drug effects
/ Memory Disorders - chemically induced
/ Memory Disorders - psychology
/ Memory, Long-Term - drug effects
/ Microscopy, Electron, Transmission
/ Occupational Medicine/Industrial Medicine
/ Rats
/ Real-Time Polymerase Chain Reaction
