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Mycobacterium tuberculosis PE_PGRS41 Enhances the Intracellular Survival of M. smegmatis within Macrophages Via Blocking Innate Immunity and Inhibition of Host Defense
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Mycobacterium tuberculosis PE_PGRS41 Enhances the Intracellular Survival of M. smegmatis within Macrophages Via Blocking Innate Immunity and Inhibition of Host Defense
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Journal Article
Mycobacterium tuberculosis PE_PGRS41 Enhances the Intracellular Survival of M. smegmatis within Macrophages Via Blocking Innate Immunity and Inhibition of Host Defense
2017
Overview
The success of
Mycobacterium tuberculosis (M. tuberculosis
) as a pathogen is largely contributes to its ability to manipulate the host immune responses. The genome of
M. tuberculosis
encodes multiple immune-modulatory proteins, including several members of the multi-genic PE_PPE family. Despite of intense research, the roles of PE_PGRS proteins in mycobacterial pathogenesis remain elusive. The function of
M. tuberculosis
PE_PGRS41, characterized by an extended and unique C-terminal domain, was studied. Expression of PE_PGRS41 in
Mycobacterium smegmatis
, a non-pathogenic species intrinsically deficient of PE_PGRS, severely impaired the resistance of the recombinant to multiple stresses via altering the cell wall integrity. Macrophages infected by
M. smegmatis
harboring PE_PGRS41 decreased the production of TNF-α, IL-1β and IL-6. In addition, PE_PGRS41 boosted the survival of
M. smegmatis
within macrophage accompanied with enhanced cytotoxic cell death through inhibiting the cell apoptosis and autophagy. Taken together, these results implicate that PE_PGRS41 is a virulence factor of
M. tuberculosis
and sufficient to confer pathogenic properties to
M. smegmatis
.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 13/31
/ 14/34
/ 14/63
/ 38/22
/ 38/23
/ 45/23
/ 45/90
/ 82/80
/ Bacterial Proteins - genetics
/ Bacterial Proteins - metabolism
/ Host-Pathogen Interactions - immunology
/ Humanities and Social Sciences
/ Immunity, Innate - immunology
/ Mycobacterium Infections, Nontuberculous - immunology
/ Mycobacterium Infections, Nontuberculous - microbiology
/ Mycobacterium smegmatis - immunology
/ Mycobacterium smegmatis - physiology
/ Science
