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Journal Article
Protein-Losing Enteropathy
2023
Overview
To the Editor:
The review of protein-losing enteropathy (PLE) by Ozen and Lenardo (Aug. 24 issue)
1
provides a vivid depiction of the two principal pathologic mechanisms — namely, intestinal mucosa damage and microcirculation drainage failure (Fig. 2 of their article). The list of potential causes, however, seems to neglect a common condition. Specifically, major surgery involves intraoperative stresses that divert blood from the enteric circulation.
2
The decreased perfusion can lead to mucosal ischemia, reduced cellular integrity, and abnormal physiological characteristics (e.g., postoperative lactose intolerance).
3
In addition, postoperative atelectasis may indirectly impair microcirculation and lymphatic drainage.
4,5
Major surgery, therefore, could provoke . . .
Publisher
Massachusetts Medical Society
