Journal Article

Driving Simulator Performance in Charcot-Marie-Tooth Disease Type 1A

Jerath, Nivedita U., Dawson, Jeffrey D., Uc, Ergun Y., Shy, Michael E., Rizzo, Matthew, Aksan, Nazan

2019

Overview

Introduction: This study evaluates driving ability in those with Charcot-Marie-Tooth Disease Type 1A, a hereditary peripheral neuropathy. Methods: Individuals with Charcot-Marie-Tooth Disease Type 1A (n = 18, age = 42 ± 7) and controls (n = 19; age = 35 ± 10) were evaluated in a driving simulator. The Charcot-Marie-Tooth Neuropathy Score version 2 was obtained for individuals. Rank Sum test and Spearman rank correlations were used for statistical analysis. Results: A 74% higher rate of lane departures and an 89% higher rate of lane deviations were seen in those with Charcot-Marie-Tooth Disease Type 1A than for controls (p = 0.005 and p < 0.001, respectively). Lane control variability was 10% higher for the individual group and correlated with the neuropathy score (rS = 0.518, p = 0.040), specifically sensory loss (rS = 0.710, p = 0.002) and pinprick sensation loss in the leg (rS = 0.490, p = 0.054). Discussion: Driving simulator assessment demonstrated more lane control errors in those with Charcot-Marie-Tooth Disease Type 1A, which correlated with lower extremity sensory loss. There was no significant difference in reported motor vehicle accidents.

• Publisher: SAE International,SAE International, a Pennsylvania Not-for Profit
• Subject: Charcot-Marie-Tooth disease / Charcot-Marie-Tooth Disease Type 1A / Charcot-Marie-Tooth Neuropathy Score version 2 / Correlation / Driving simulator / Genetic aspects / Lane changing / Motor vehicles / Peripheral neuropathy / Questionnaires / Sensory loss / Simulation / Statistical analysis / Vehicles