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Simplified Method for Local Correction of System International Normalized Ratio
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Journal Article
Simplified Method for Local Correction of System International Normalized Ratio
2017
Overview
Abstract
Background
International normalized ratio (INR) derivation is dependent on the international sensitivity index (ISI) of thromboplastin. It varies with instrument and reagents used.
Objective
To evaluate the role of a correction factor in the derivation of INR.
Methods
We studied prothrombin time (PT) and INR from patients using 3 thromboplastins of varying ISI values. The correction factor was applied to the observed INR to obtain a corrected INR.
Results
The difference between corrected INR and observed INR values varies from −0.8 through 0.96.
Conclusions
Corrected INR is dependent on PT only. It can be applied to all patients irrespective of cause for elevated PT.
Publisher
Oxford University Press
