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A generalized Dunnett test for multi-arm multi-stage clinical studies with treatment selection
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Journal Article
A generalized Dunnett test for multi-arm multi-stage clinical studies with treatment selection
2012
Overview
We generalize the Dunnett test to derive efficacy and futility boundaries for a flexible multi-arm multistage clinical trial for a normally distributed endpoint with known variance. We show that the boundaries control the familywise error rate in the strong sense. The method is applicable for any number of treatment arms, number of stages and number of patients per treatment per stage. It can be used for a wide variety of boundary types or rules derived from á-spending functions. Additionally, we show how sample size can be computed under a least favourable configuration power requirement and derive formulae for expected sample sizes.
Publisher
Biometrika Trust, University College London,Oxford University Press,Oxford Publishing Limited (England)
