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Effect of fexofenadine/pseudoephedrine combination tablet on nasal obstruction in patients with allergic rhinitis using rhinomanometry: A randomized controlled trial
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Effect of fexofenadine/pseudoephedrine combination tablet on nasal obstruction in patients with allergic rhinitis using rhinomanometry: A randomized controlled trial
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Effect of fexofenadine/pseudoephedrine combination tablet on nasal obstruction in patients with allergic rhinitis using rhinomanometry: A randomized controlled trial
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Journal Article
Effect of fexofenadine/pseudoephedrine combination tablet on nasal obstruction in patients with allergic rhinitis using rhinomanometry: A randomized controlled trial
2024
Overview
A fexofenadine/pseudoephedrine combination tablet (F/P) is an optimal product for nasal obstruction. It contains fexofenadine hydrochloride, a histamine H1-receptor antagonist for sneezing and rhinorrhea and pseudoephedrine hydrochloride, an α-adrenergic agonist. The effect of an antihistamine-decongestant on nasal obstruction has been demonstrated in previous studies, but onset of action and efficacy data on nasal obstruction are limited.
We estimated the efficacy of F/P on nasal obstruction in patients with house dust mite-induced allergic rhinitis (AR) versus fexofenadine (F) using objective methods.
In this single-center, single-dose, prospective, randomized, parallel-group study, 24 adult patients with a history of at least 2 years of AR and nasal obstruction were randomized to receive F/P or F. The effect on nasal obstruction was evaluated using nasal airflow and visual analog scale (VAS) score measured at 30-minute intervals before and for 8 hours after dosing. The primary end point was onset of action, based on a comparison of absolute change from baseline in nasal airflow between F/P and F. The protocol was registered in a clinical trial registry as UMIN 000041845.
The onset of action for F/P was 30 minutes based on nasal airflow and 60 minutes based on VAS. F/P maintained a significant beneficial effect after onset of effect, while F showed no significant change during the test period.
We found F/P had a clear effect on nasal obstruction associated with perennial AR when compared with F. There was a time lag in nasal airflow improvement and nasal obstruction relief.
Publisher
The Allergy and Immunology Society
Subject
/ Dosage
/ Female
/ Histamine H1 Antagonists, Non-Sedating - administration & dosage
/ Histamine H1 Antagonists, Non-Sedating - therapeutic use
/ Humans
/ Male
/ Nasal Decongestants - administration & dosage
/ Nasal Decongestants - therapeutic use
/ Nasal Obstruction - diagnosis
/ Nasal Obstruction - drug therapy
/ Nasal Obstruction - etiology
/ Pseudoephedrine - administration & dosage
/ Pseudoephedrine - therapeutic use
/ Rhinitis
/ Rhinitis, Allergic - complications
/ Rhinitis, Allergic - drug therapy
/ Tablets
/ Terfenadine - administration & dosage
/ Terfenadine - analogs & derivatives
