Journal Article

Green Synthesis of SnO2 Nanoparticles from Laurus nobilis L. Extract for Enhanced Gelatin-Based Films and CEF@SnO2 for Efficient Antibacterial Activity

Kir, Iman, Abdullah, Johar Amin Ahmed, Mohammed, Hamdi Ali, Eddine, Laouini Salah, Hasan, Gamil Gamal, Souhaila, Meneceur

2024

Overview

The green synthesis method was used to prepare SnO 2 nanoparticles (NPs) from Laurus nobilis L. aqueous extract. Gelatin-based films are a promising substitute for traditional plastics due to their eco-friendliness, low cost, and pliability. However, they have some drawbacks such as high water solubility, poor opacity, and permeability to vapor. The use of synthesized SnO 2 NPs can help address these concerns. The GEL/SnO 2 film has enhanced morphological and physicochemical properties, with antibacterial properties that could extend the shelf life of perishable items like strawberries, contributing to reducing food waste. To improve their antibacterial activity, the SnO 2 NPs were functionalized with the cefazolin (CEF) drug. The synthesized SnO 2 NPs and the CEF@SnO 2 nanocomposite (NC) were characterized using various techniques such as UV-Vis, FTIR, SEM, and XRD. The results showed that the particle sizes of SnO 2 NPs and CEF@SnO 2 NC were 28 nm and 35 nm, respectively, and SEM analysis revealed spherical-shaped agglomerated particles for both. The optical bandgap energy was calculated to be 3.3 and 2.34 eV for SnO 2 NPs and CEF@SnO 2 NC, respectively. The antibacterial activity exhibits an excellent inhibition zone for synthesized SnO2 NPs and the CEF@SnO 2 NC with different concentrations (1, 3, and 5 mM) against Escherichia coli , Pseudomonas aeruginosa , and Staphylococcus aureus . CEF@SnO 2 NC revealed a strong effect compared to SnO 2 NPs, where 5 mM shows the highest inhabitation zone. Molecular docking studies supported the experimental data, indicating the interaction between proteins and the CEF@SnO 2 . This approach offers an innovative way of synthesizing drug-loaded SnO 2 NPs as functional biomaterials.

• Publisher: Springer US,Springer Nature B.V
• Subject: Agriculture / Antibacterial activity / antibacterial properties / biocompatible materials / Biomaterials / Biomedical materials / bioprocessing / Biotechnology / Cefazolin / Chemistry / Chemistry and Materials Science / Chemistry/Food Science / E coli / energy / Escherichia coli / Food Science / Food waste / Gelatin / Laurus nobilis / Molecular docking / Nanocomposites / Nanoparticles / Opacity / Permeability / Physicochemical properties / Pseudomonas aeruginosa / Shelf life / Staphylococcus aureus / Synthesis / Tin dioxide / water solubility