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Allergenicity determination of Turbot parvalbumin for safety of fish allergy via dendritic cells, RBL‐2H3 cell and mouse model
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Allergenicity determination of Turbot parvalbumin for safety of fish allergy via dendritic cells, RBL‐2H3 cell and mouse model
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Allergenicity determination of Turbot parvalbumin for safety of fish allergy via dendritic cells, RBL‐2H3 cell and mouse model
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Journal Article
Allergenicity determination of Turbot parvalbumin for safety of fish allergy via dendritic cells, RBL‐2H3 cell and mouse model
2021
Overview
Fish as an important food source, with the increase of consumption rate, the resulting allergic phenomenon increased year by year. Food allergen in aquatic products was an important allergy-inducing factor, which had a great impact on the body’s tissue, inflammatory factors, immunoglobulin and intestinal flora. The research objective of this study was to evaluate the allergenic risk of turbot parvalbumin (PV) and provided effective biological reference markers for the safety assessment of aquatic products. Results showed PV has high purity, high binding capacity with IgE and IgG, influenced release of inflammatory factors in DCs (IL-6/10/12p70), induced allergic response in mice. PV increased the levels of PV-specific IgE, total IgE, IgG1, monocyte chemotactic protein 1(MCP-1), histamine, tryptase significantly. PV obviously mutagenic effect on spleen, intestinal tissue. Sequencing of microbial diversity showed that microorganism Ruminiclostridium and Alistipes in PV group changed significantly, which proved that the structure of intestinal microorganism has changed. In summary, Turbot parvalbumin triggered fish allergic responses by induced imbalance of inflammatory factors and microbial composition of IL-6/10/12p70, IgE/IgG and Ruminiclostridium, Alistipes. These results indicated that PV had high-risk allergy inducing ability, and the changes of the above indicators provided biological reference markers for risk assessment of the safety of aquatic products intake.Graphic abstract
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