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Promoting wound healing using Cyanothece sp. in the rat model
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Promoting wound healing using Cyanothece sp. in the rat model
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Journal Article
Promoting wound healing using Cyanothece sp. in the rat model
2024
Overview
The current study investigated the healing effects of polysaccharides and lipid extracts obtained from the cyanobacterium
Cyanothece
sp. on burn wounds in the rat model. This halophilic cyanobacterial species was originally isolated from Pink Lake (Lipar Lake) located on the margins of Oman Gulf, southeast Iran. A total of 40 white Wistar male rats were subjected to burn injuries and were allocated into four distinct experimental groups, each comprising 10 rats: the control group, standard group, polysaccharide group, and lipid group that were treated with Eucerin, Alpha ointment,
Cyanothece
sp. polysaccharide ointment (5% Eucerin-based), and
Cyanothece
sp. lipid ointment (5% Eucerin-based). The healing efficacy of the cyanobacterial components was evaluated by examining histopathological, morphological, hormonal, and inflammatory response changes in the rats. The cyanobacterial ointments, especially the lipid ointment, significantly enhanced wound healing by inducing cell proliferation, increasing blood vessel counts, wound closure rates, epithelial thickness, fibroblast numbers, and collagen density in the treated rats (
p
<0.05). Furthermore, the ointment substantially reduced wound secretions and inflammatory markers, including tumor necrosis factor-alpha (TNFα), interleukins (IL)-2 and IL-8, neutrophil counts, C-reactive protein (CRP), cortisol, and adrenocorticotropic hormone (ACTH). GC-MS analysis identified fatty acid components in the extracted lipids, such as palmitic acid (31.98%), octadecanoic acid (12.86%), oleic acid (8.22%), palmitoleic acid (4.89%), α-linolenic (4.5%), elaidic acid (4.14%), and decanoic acid (3.31%) which are believed to contribute significantly to the wound repair process.
Graphical Abstract
