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Orally administered oxygen nanobubbles enhance tumor response to sonodynamic therapy
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Orally administered oxygen nanobubbles enhance tumor response to sonodynamic therapy
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Orally administered oxygen nanobubbles enhance tumor response to sonodynamic therapy
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Journal Article
Orally administered oxygen nanobubbles enhance tumor response to sonodynamic therapy
2022
Overview
Suspensions of oxygen‐filled bubbles are under active investigation as potential means of relieving tissue hypoxia. Intravenous administration of large quantities of bubbles is, however, undesirable. Previous work by the authors has demonstrated that tumor oxygen levels can be increased following oral administration of phospholipid stabilized oxygen nanobubbles. The aim of this study was to determine whether this would enhance the efficacy of sonodynamic therapy (SDT), which is known to be inhibited in hypoxic tissue. Experiments were conducted in a murine model of pancreatic cancer. Animals were treated with SDT (intratumoural injection of 1 mM Rose Bengal followed by exposure to 1 MHz ultrasound, 0.1 kHz pulse repetition frequency, 30% duty cycle, 3.5 W cm−2 for 3.5 minutes) either with or without a prior gavage of oxygen bubbles. A statistically significant reduction in the rate of tumor growth was observed in the groups receiving oxygen nanobubbles either 5 or 20 minutes before SDT. Separate measurements of tumor oxygen using a fiber optic probe and expression of hypoxia inducible factor (HIF)1α following tumor excision, confirmed the change in tumor oxygen levels. These findings offer a potentially promising new approach to relieving tissue hypoxia in order to facilitate cancer therapy. The response of a human pancreatic tumor model to sonodynamic therapy is improved by an orally administered suspension of lipid‐stabilized oxygen nanobubbles. Quantification of oxygen loading indicates that the bubbles may be acting as re‐circulating oxygen carriers, enabling tumor oxygenation over prolonged periods.
