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A Nuclear Hormone Receptor nhr‐76 Induces Age‐Dependent Chemotaxis Decline in C. elegans
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A Nuclear Hormone Receptor nhr‐76 Induces Age‐Dependent Chemotaxis Decline in C. elegans
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A Nuclear Hormone Receptor nhr‐76 Induces Age‐Dependent Chemotaxis Decline in C. elegans
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Journal Article
A Nuclear Hormone Receptor nhr‐76 Induces Age‐Dependent Chemotaxis Decline in C. elegans
2025
Overview
A decline in food‐searching behavior of post‐reproductive animals can benefit the population and possibly be programmed by the genome despite its detrimental effect on an individual. We investigated the genetic program of age‐dependent decline in chemotaxis behavior toward an odorant secreted from bacterial food in C. elegans. Through a novel forward genetic screen, we identified the gene encoding a nuclear hormone receptor, nhr‐76, whose mutants ameliorate the age‐dependent chemotaxis decline. We found that NHR‐76 downregulates odorant receptor expression during aging in a ligand‐binding‐domain–dependent manner. Since NHR‐76 expression and localization remain unchanged with age, its activity may be modulated through the ligand‐binding domain, leading to age‐dependent chemotaxis decline. Our findings imply that post‐reproductive behavioral decline can be genetically programmed. A forward genetic screen in C. elegans identified a nuclear hormone receptor, nhr‐76, as a gene that programs age‐dependent behavioral decline. In post‐reproductive adults, NHR‐76 downregulates odr‐10 that encodes an odorant receptor, leading to impaired chemotaxis.
Publisher
John Wiley & Sons, Inc
Subject
/ Aging
/ Animals
/ Behavior
/ Caenorhabditis elegans - genetics
/ Caenorhabditis elegans - metabolism
/ Caenorhabditis elegans - physiology
/ Caenorhabditis elegans Proteins - genetics
/ Caenorhabditis elegans Proteins - metabolism
/ Males
/ Mutation
/ Receptors, Cytoplasmic and Nuclear - genetics
/ Receptors, Cytoplasmic and Nuclear - metabolism
/ Receptors, Odorant - genetics
