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T cells from patients with Parkinson’s disease recognize α-synuclein peptides

by Kanter, Ellen , Phillips, Elizabeth , Hildebrand, William H. , Weiskopf, Daniela , Frazier, April , Sulzer, David , Peters, Bjoern , Dawson, Valina L. , Agin-Liebes, Julian , Sette, Alessandro , McMurtrey, Curtis , Oseroff, Carla , Carpenter, Chelsea , Mallal, Simon , Cote, Lucien , Sidney, John , Liong, Christopher , Dawson, Ted M. , Alcalay, Roy N. , Pham, John , Dillon, Myles B. , Lindestam Arlehamn, Cecilia S. , Garretti, Francesca , Mao, Xiaobo

in Aged / Aged, 80 and over / Alleles / alpha-Synuclein - chemistry / alpha-Synuclein - immunology / Amino Acid Sequence / Amino acids / Antigens / Autoimmunity / Cytokines / Cytotoxicity / Dopamine / Epitopes / Epitopes, T-Lymphocyte - immunology / Female / HLA Antigens - genetics / HLA Antigens - immunology / Humans / Lymphocytes / Lymphocytes T / Major histocompatibility complex / Male / Middle Aged / Movement disorders / Neurodegenerative diseases / Parkinson Disease - genetics / Parkinson Disease - immunology / Parkinson Disease - pathology / Parkinson's disease / Patients / Peptide Fragments - chemistry / Peptide Fragments - immunology / Peptides / Proteins / Synuclein / T-Lymphocytes - immunology / T-Lymphocytes - pathology / T-Lymphocytes, Cytotoxic - immunology / T-Lymphocytes, Cytotoxic - pathology / T-Lymphocytes, Helper-Inducer - immunology / T-Lymphocytes, Helper-Inducer - pathology

2017

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T cells from patients with Parkinson’s disease recognize α-synuclein peptides

2017

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2017

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Journal Article

T cells from patients with Parkinson’s disease recognize α-synuclein peptides

Kanter, Ellen,

Phillips, Elizabeth,

Hildebrand, William H.,

Weiskopf, Daniela,

Frazier, April,

Sulzer, David,

Peters, Bjoern,

Dawson, Valina L.,

Agin-Liebes, Julian,

Sette, Alessandro,

McMurtrey, Curtis,

Oseroff, Carla,

Carpenter, Chelsea,

Mallal, Simon,

Cote, Lucien,

Sidney, John,

Liong, Christopher,

Dawson, Ted M.,

Alcalay, Roy N.,

Pham, John,

Dillon, Myles B.,

Lindestam Arlehamn, Cecilia S.,

Garretti, Francesca,

Mao, Xiaobo

2017

Overview

Genetic studies have shown the association of Parkinson's disease with alleles of the major histocompatibility complex. Here we show that a defined set of peptides that are derived from α-synuclein, a protein aggregated in Parkinson's disease, act as antigenic epitopes displayed by these alleles and drive helper and cytotoxic T cell responses in patients with Parkinson's disease. These responses may explain the association of Parkinson's disease with specific major histocompatibility complex alleles.

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Publisher

Nature Publishing Group

Subject

Aged

/ Aged, 80 and over

/ Alleles

/ alpha-Synuclein - chemistry

/ alpha-Synuclein - immunology

/ Amino Acid Sequence

/ Amino acids