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2-oxo-PCE: ketamine analogue on the streets
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Journal Article
2-oxo-PCE: ketamine analogue on the streets
2017
Overview
An unidentified substance was detected in these samples by general toxicology screening using high-performance liquid chromatography-diode array detection; further investigations at our laboratory confirmed the unidentified substance as 2-oxo-PCE by liquid chromatography-tandem mass spectrometry. Historically, it was synthesised in 1962 in an attempt to develop a short-acting phencyclidine derivative, a project that culminated in the discovery of ketamine.4 Drugs of this class are known to possess N-methyl-D-aspartate receptor antagonist activity with variable effects towards other receptors,4 resulting in dissociative effects clinically. YK Chong 1,2; Magdalene HY Tang 1; CL Chan 2; YK Li 3; CK Ching 1,2; Tony WL Mak 1,2 1 Hospital Authority Toxicology Reference Laboratory, Princess Margaret Hospital, Laichikok, Hong Kong 2 Chemical Pathology Laboratory, Department of Pathology, Princess Margaret Hospital, Laichikok, Hong Kong 3 Accident and Emergency Department, Princess Margaret Hospital, Laichikok, Hong Kong
Publisher
Hong Kong Academy of Medicine
