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Gastroprotective Effects of DA-6034, a New Flavonoid Derivative, in Various Gastric Mucosal Damage Models
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Gastroprotective Effects of DA-6034, a New Flavonoid Derivative, in Various Gastric Mucosal Damage Models
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Gastroprotective Effects of DA-6034, a New Flavonoid Derivative, in Various Gastric Mucosal Damage Models
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Journal Article
Gastroprotective Effects of DA-6034, a New Flavonoid Derivative, in Various Gastric Mucosal Damage Models
2007
Overview
This study evaluated the gastroprotective activity of DA-6034 against various ulcerogens including ethanol, aspirin, indomethacin, stress, and acetic acid. The basic mechanisms of DA-6034 as a defensive factor such as mucus secretion and endogenous prostaglandin E(2) synthesis were determined. Rats with gastric lesions induced by ethanol-HCl, aspirin, indomethacin, and stress that had been pretreated with DA-6034 orally showed a statistically significant decrease or decreasing tendency of the gastric lesion. In acetic acid-induced gastric lesions, repeated oral administration of DA-6034 exhibited a U-shape activity in ulcer healing, with the maximum and minimum inhibition being observed at 30 and 10 mg/kg/day, respectively. DA-6034 also increased the mucus content in the gel layer as well as endogenous prostaglandin E(2) synthesis. These results suggest that DA-6034 prevents gastric mucosal injury, and these gastroprotective activities appear to be due to the increase in the gastric defensive systems.
Publisher
Springer,Springer Nature B.V
Subject
/ Animals
/ Anti-Inflammatory Agents, Non-Steroidal - toxicity
/ Biological and medical sciences
/ Bones, joints and connective tissue. Antiinflammatory agents
/ Central Nervous System Depressants - toxicity
/ Flavonoids - administration & dosage
/ Fundamental and applied biological sciences. Psychology
/ Gastric Mucosa - drug effects
/ Indicators and Reagents - toxicity
/ Male
/ Pharmacology. Drug treatments
/ Rats
/ Stomach Ulcer - prevention & control
/ Stress, Psychological - complications
/ Vertebrates: anatomy and physiology, studies on body, several organs or systems
