Journal Article

A randomized prospective study to compare the efficacy of 308-nm light-emitting diode and 308-nm excimer lamp in the treatment of facial vitiligo

Xu, Zhuohong, Zhang, Liangliang, Luan, Chao, Chen, Lihao, Liu, Lihao, Chen, Hongying, Chen, Kun, Huang, Dan, Ju, Mei, Zhang, Jiaan, Hu, Yu, Dai, Xiaoxi

2025

Overview

Background Previous studies have proven that 308-nm light-emitting diode(308-nm LED)and 308-nm excimer lamp(308-nm MEL) are effective in treating vitiligo, but there is a lack of comparison of their efficacy for facial lesions. Objective To evaluate and contrast the treatment success rates of 308-nm LED versus 308-nm excimer lamp in managing facial lesions among patients suffering from stable non-segmental vitiligo. Methods The enrolled 119 patients with 145 lesions were randomly assigned to receive 308-nm LED or 308-nm MEL for two months. Two independent investigators graded repigmentation at the end of the 2-month treatment period. Results There were 76 lesions in the 308-nm LED group and 69 in the 308-nm MEL group. After 1 month, the average repigmentation grade of the 308-nm LED group was 1.34, with an efficacy rate of 11.84%, and the average repigmentation grade of the 308-nm MEL group was 1.17, with an efficacy rate of 7.24%.After two months of phototherapy, the average repigmentation grade of the 308-nm LED group was 2.38, and the effective rate was 42.1%. The average repigmentation grade in the 308-nm MEL group was 2.19, and the effective rate was 39.12%. The two light sources had similar effects on facial vitiligo lesions after 1 month and 2 months of treatment( P  =.349, P  =.416), and the incidence of side effects was also comparable between the two groups ( P  =.332). Conclusion The 308-nm LED is as effective and safe as 308-nm MEL in treating stable non-segmental facial vitiligo lesions.

• Publisher: Springer Berlin Heidelberg,Springer Nature B.V
• Subject: Adolescent / Adult / Chi-square test / Child / Dermatology / Erythema / Face / Female / Humans / Lasers, Excimer - therapeutic use / Lesions / Light effects / Light emitting diodes / Light therapy / Low-Level Light Therapy - adverse effects / Low-Level Light Therapy - instrumentation / Low-Level Light Therapy - methods / Male / Medicine / Medicine & Public Health / Middle Aged / Original Paper / Phototherapy / Prospective Studies / Skin / Skin Pigmentation - radiation effects / Statistical analysis / Treatment Outcome / Vitiligo / Vitiligo - diagnosis / Vitiligo - radiotherapy / Vitiligo - therapy / Young Adult