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Apoptosis and Microvessel Density in Gastric Cancer: Correlation with Tumor Stage and Prognosis
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Apoptosis and Microvessel Density in Gastric Cancer: Correlation with Tumor Stage and Prognosis
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Journal Article
Apoptosis and Microvessel Density in Gastric Cancer: Correlation with Tumor Stage and Prognosis
2009
Overview
Gastric cancer remains one of the most common human malignancies with a poor prognosis. Apoptosis is known to be a programmed cell death and its inhibition is involved in the unregulated cellular growth that leads to neoplasms. Microvessel density (MVD) has been investigated as a promoting factor for angiogenesis with conflicting results about its relation to survival. The aim of our study was to search a correlation between these factors and some clinicopathological features and prognosis. Identification of apoptotic cells was performed applying the terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling technique and recorded as apoptotic index (A.I.), whereas monoclonal antibodies were used for the study of MVD. A significant correlation was found between low and high A.I. and the subgroup of patients in Stages I and II (P < 0.02); 20 per cent of patients with a low A.I. showed an overall survival longer than 5 years versus 44 per cent of patients with an high A.I. (P = 0.041). High MVD was significantly related to the T stage ( P = 0.036) and to a poorer 5-year overall survival (P < 0.05). Further studies are required to confirm the role of apoptosis and MVD in the development and progression of gastric cancer.
Publisher
Southeastern Surgical Congress,SAGE PUBLICATIONS, INC
Subject
/ Aged
/ Biological and medical sciences
/ Female
/ Gastroenterology. Liver. Pancreas. Abdomen
/ Humans
/ Male
/ Proteins
/ Stomach Neoplasms - blood supply
/ Stomach Neoplasms - pathology
/ Stomach Neoplasms - physiopathology
/ Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
/ Studies
/ Tumors
