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Evaluation of Cyclotron Solid Target Produced Gallium-68 Chloride for the Labeling of 68GaGa-PSMA-11 and 68GaGa-DOTATOC
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Evaluation of Cyclotron Solid Target Produced Gallium-68 Chloride for the Labeling of 68GaGa-PSMA-11 and 68GaGa-DOTATOC
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Evaluation of Cyclotron Solid Target Produced Gallium-68 Chloride for the Labeling of 68GaGa-PSMA-11 and 68GaGa-DOTATOC
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Journal Article
Evaluation of Cyclotron Solid Target Produced Gallium-68 Chloride for the Labeling of 68GaGa-PSMA-11 and 68GaGa-DOTATOC
2025
Overview
Gallium-68 is a widely used positron-emitting radionuclide in nuclear medicine, traditionally obtained from 68Ge/68Ga generators. However, increasing clinical demand has driven interest in alternative production methods, such as medical cyclotrons equipped with solid targets. This study evaluates the functional equivalence of gallium-68 chloride obtained from cyclotron solid target and formulated to be equivalent to the eluate from a germanium-gallium generator, aiming to determine whether this production method can serve as a reliable alternative for PET radiopharmaceutical applications. Preparations of [68Ga]Ga-PSMA-11 and [68Ga]Ga-DOTATOC, labeled with cyclotron-derived gallium-68 chloride, were subjected to quality control analysis using radio thin layer chromatography and radio high performance liquid chromatography. Subsequently, biodistribution studies were performed in mouse oncological models of expression of PSMA antigen and SSTR receptor to compare uptake of preparations produced with generator and cyclotron-derived isotopes. All tested formulations met the required radiochemical purity specifications. Moreover, tumor accumulation of the radiolabeled compounds was comparable regardless of the isotope source. The results support the conclusion that gallium-68 produced via cyclotron is functionally equivalent to that obtained from a generator, demonstrating its potential for interchangeable use in clinical and research radiopharmaceutical applications.
Publisher
MDPI AG
Subject
/ Animals
/ Chloride
/ Cold
/ Edetic Acid - analogs & derivatives
/ Gallium Radioisotopes - chemistry
/ Humans
/ Isotopes
/ Mice
/ Octreotide - analogs & derivatives
/ Organometallic Compounds - chemistry
/ Peptides
/ Positron-Emission Tomography
/ Prostate
/ Radiopharmaceuticals - chemistry
