Asset Details
Do you wish to reserve the book?
Design and analysis of microfluidic cell counter using spice simulation
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Design and analysis of microfluidic cell counter using spice simulation
Do you wish to request the book?
Design and analysis of microfluidic cell counter using spice simulation
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Design and analysis of microfluidic cell counter using spice simulation
2019
Overview
Microfluidic cytometers based on Coulter principle have recently shown a great potential for point of care biosensors for medical diagnostics. In this study, the design and characterization of Coulter-based microfluidic cytometer are investigated through electrical circuit simulations considering an equivalent electrical model for the biological cell. We explore the effects related to microelectrode dimensions, microfluidic detection volume, suspension medium, size/morphology of the target cells, and the impedance of the external readout circuit, on the output response of the sensor. We show that the effect of microelectrodes’ surface area and the dielectric properties of the suspension medium should be carefully considered when characterizing the output response of the sensor. In particular, the area of the microelectrodes can have a significant effect on cell’s electrical opacity (the ratio of cell impedance at high to low frequency) which is commonly used to distinguish between subpopulations of the target cells (e.g., lymphocytes vs. monocytes when counting white blood cells). Moreover, we highlight that the opacity response versus frequency can significantly vary based upon whether the absolute cell impedance or the differential output impedance is used in its calculation. These insights could provide valuable guidelines for the design and characterization of Coulter-based microfluidic sensors.
Publisher
Springer International Publishing,Springer Nature B.V
Subject
