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Association between Lenticulostriate Vasculopathy (LSV) and Neonatal Intraventricular Hemorrhage (IVH)
by
Mittendorf, Robert
, Covert, Robert
, Pryde, Peter G
, Lee, Kwang-Sun
, Ben-Ami, Tamar
, Yousefzadeh, David
in
Basal Ganglia Cerebrovascular Disease - complications
/ Blood circulation disorders
/ Care and treatment
/ Cerebral Hemorrhage - etiology
/ Comparative analysis
/ Confidence intervals
/ Diseases
/ Dosage and administration
/ Fetuses
/ Hemorrhage
/ Humans
/ Infant, Newborn
/ Infants (Newborn)
/ Infusion therapy
/ Magnesium sulfate
/ Medicine
/ Medicine & Public Health
/ Morbidity
/ Neonates
/ Newborn babies
/ original-article
/ Pediatric Surgery
/ Pediatrics
/ Prenatal exposure
/ Statistical analysis
/ Vascular diseases
2004
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Association between Lenticulostriate Vasculopathy (LSV) and Neonatal Intraventricular Hemorrhage (IVH)
by
Mittendorf, Robert
, Covert, Robert
, Pryde, Peter G
, Lee, Kwang-Sun
, Ben-Ami, Tamar
, Yousefzadeh, David
in
Basal Ganglia Cerebrovascular Disease - complications
/ Blood circulation disorders
/ Care and treatment
/ Cerebral Hemorrhage - etiology
/ Comparative analysis
/ Confidence intervals
/ Diseases
/ Dosage and administration
/ Fetuses
/ Hemorrhage
/ Humans
/ Infant, Newborn
/ Infants (Newborn)
/ Infusion therapy
/ Magnesium sulfate
/ Medicine
/ Medicine & Public Health
/ Morbidity
/ Neonates
/ Newborn babies
/ original-article
/ Pediatric Surgery
/ Pediatrics
/ Prenatal exposure
/ Statistical analysis
/ Vascular diseases
2004
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Association between Lenticulostriate Vasculopathy (LSV) and Neonatal Intraventricular Hemorrhage (IVH)
by
Mittendorf, Robert
, Covert, Robert
, Pryde, Peter G
, Lee, Kwang-Sun
, Ben-Ami, Tamar
, Yousefzadeh, David
in
Basal Ganglia Cerebrovascular Disease - complications
/ Blood circulation disorders
/ Care and treatment
/ Cerebral Hemorrhage - etiology
/ Comparative analysis
/ Confidence intervals
/ Diseases
/ Dosage and administration
/ Fetuses
/ Hemorrhage
/ Humans
/ Infant, Newborn
/ Infants (Newborn)
/ Infusion therapy
/ Magnesium sulfate
/ Medicine
/ Medicine & Public Health
/ Morbidity
/ Neonates
/ Newborn babies
/ original-article
/ Pediatric Surgery
/ Pediatrics
/ Prenatal exposure
/ Statistical analysis
/ Vascular diseases
2004
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Association between Lenticulostriate Vasculopathy (LSV) and Neonatal Intraventricular Hemorrhage (IVH)
Journal Article
Association between Lenticulostriate Vasculopathy (LSV) and Neonatal Intraventricular Hemorrhage (IVH)
2004
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Overview
OBJECTIVES:
To determine whether there is an unconfounded association between neonatal intraventricular hemorrhage (IVH) and lenticulostriate vasculopathy (LSV (also known as thalamostriate or mineralizing vasculopathy)).
STUDY DESIGN:
During the conduct of the Magnesium and Neurologic Endpoints Trial (MagNET), a randomized controlled trial involving maternal, hence fetal, exposure to antenatal magnesium sulfate in the context of preterm labor, head ultrasounds were obtained for each of the surviving neonates. Because of our previous experience in the diagnosis of LSV, when ascertaining the presence of IVH, as called for by the research protocol of our study, the presence or absence of LSV was also determined.
RESULTS:
We found LSV to be relatively prevalent (10% (14 of 140) among surviving babies). More importantly, it was significantly associated with the occurrence of neonatal IVH, even when controlled for possible confounding (adjusted OR 9.8, 95% confidence interval 1.3 to 73.1;
p
=0.03).
CONCLUSION:
Given the known relationships between IVH and neonatal morbidity and mortality, the finding of a statistically significant association between neonatal IVH and LSV may suggest more substantial implications for the latter than previously believed.
Publisher
Nature Publishing Group US,Nature Publishing Group
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