Journal Article

Amlodipine‐Based Therapy and Its Effect on Time in Target Range and Long‐Term Blood Pressure Variability Across Age Groups in Chinese Patients With Primary Hypertension: A Retrospective Study

Sun, Ningling, Lin, Jinxiu, Chen, Shuling, Peng, Feng, Chai, Dajun, Yang, Jinghan

2025

Overview

This study aimed to compare systolic blood pressure (SBP) time in target range (TTR), long‐term blood pressure (BP) variability (BPV), and BP control across age groups (18–45, 46–64, 65–79, ≥80 years) in patients with primary hypertension treated with amlodipine‐based antihypertensive therapy for ≥12 months. Data were obtained from adult patients enrolled in the China Hypertension Center who received amlodipine‐based antihypertensive therapy. Demographics, BP measurements, and laboratory results were recorded. Baseline characteristics, SBP TTR, long‐term BPV, and BP control were compared among age groups. A total of 36 153 patients were included: 2681 in the 18–45 group, 14 300 in the 46–64 group, 15 595 in the 65–79 group, and 3577 in the ≥ 80 group. Younger and middle‐aged patients demonstrated better indicator improvements. SBP TTR declined with age (82.52% ± 19.68%, 81.98% ± 20.69%, 79.10% ± 22.96%, and 78.33% ± 23.50%, respectively; p < 0.001). BP control also declined with age (84.04%, 83.20%, 80.44%, and 79.59%, respectively; p < 0.001). BPV increased with age, though not significantly (p = 0.051). During follow‐up, SBP TTR and BP control improved, while BPV declined, with most changes reaching statistical significance. Across all age groups, SBP TTR remained above 78% throughout follow‐up. Long‐term continuous use of amlodipine is beneficial for achieving improved BP control, enhanced TTR, and reduced BPV.

• Publisher: John Wiley & Sons, Inc,Wiley
• Subject: Adolescent / Adult / Age Factors / Age groups / Aged / Aged, 80 and over / amlodipine / Amlodipine - administration & dosage / Amlodipine - pharmacology / Amlodipine - therapeutic use / Antihypertensive Agents - administration & dosage / Antihypertensive Agents - therapeutic use / Antihypertensives / Blood pressure / Blood Pressure - drug effects / Blood Pressure - physiology / blood pressure control rate / Blood Pressure Determination - methods / blood pressure variability / China - epidemiology / East Asian People / Female / Humans / Hypertension / Hypertension - drug therapy / Hypertension - epidemiology / Hypertension - physiopathology / Male / Middle Aged / Retrospective Studies / Time Factors / time in target range / Treatment Outcome / Young Adult