Journal Article

Entrapped Transient Chloroform Solvates of Bilastine

Puigjaner, Cristina, Font-Bardia, Mercè, Vallcorba, Oriol, Blasco, Arturo, Portell, Anna

2021

Overview

The knowledge about the solid forms landscape of Bilastine (BL) has been extended. The crystal structures of two anhydrous forms have been determined, and the relative thermodynamic stability among the three known anhydrous polymorphs has been established. Moreover, three chloroform solvates with variable stoichiometry have been identified and characterized, showing that S3CHCl3-H2O and SCHCl3 can be classified as transient solvates which transform into the new chloroform solvate SCHCl3-H2O when removed from the mother liquor. The determination of their crystal structures from combined single crystal/synchrotron X-ray powder diffraction data has allowed the complete characterization of these solvates, being two of them heterosolvates (S3CHCl3-H2O and SCHCl3-H2O) and SCHCl3 a monosolvate. Moreover, the temperature dependent stability and interrelation pathways among the chloroform solvates and the anhydrous forms of BL have been studied.

• Publisher: MDPI AG
• Subject: bilastine / Chloroform / Crystal structure / crystal structure determination / Experiments / Pharmaceutical industry / polymorph / Radiation / Sensors / single crystal X-ray diffraction / Single crystals / solvate / Solvents / Stability / Stoichiometry / structure determination from powder diffraction / Synchrotron radiation / Synchrotrons / Temperature dependence / X ray powder diffraction