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Expression of miR-208b and miR-499 in Greek Patients with Acute Myocardial Infarction

by Nasioulas, George , Bampali, Konstantina , Babalis, Dimitrios , Agiannitopoulos, Konstantinos , Lamnissou, Klea , Samara, Pinelopi , Pavlopoulou, Panagiota , Tsamis, Konstantinos , Mertzanos, George

in Aged / Biomarkers / Blood & organ donations / Cardiomyocytes / Case-Control Studies / Circulating MicroRNA / Female / Gene Expression / Gene Expression Profiling / Greece / Heart attacks / Humans / Kinases / Liquid Biopsy / Male / MicroRNAs / MicroRNAs - genetics / Middle Aged / Musculoskeletal system / Myocardial Infarction - blood / Myocardial Infarction - genetics / Plasma / Risk Factors / ROC Curve

2018

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Expression of miR-208b and miR-499 in Greek Patients with Acute Myocardial Infarction

2018

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Expression of miR-208b and miR-499 in Greek Patients with Acute Myocardial Infarction

2018

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Journal Article

Expression of miR-208b and miR-499 in Greek Patients with Acute Myocardial Infarction

Nasioulas, George,

Bampali, Konstantina,

Babalis, Dimitrios,

Agiannitopoulos, Konstantinos,

Lamnissou, Klea,

Samara, Pinelopi,

Pavlopoulou, Panagiota,

Tsamis, Konstantinos,

Mertzanos, George

2018

Overview

Certain microRNAs (miRs) present in human plasma are candidate biomarkers for cardiovascular diseases, including acute myocardial infarction (AMI). We examined the expression of two cardiac-specific miRs (miR-208b and miR-499) in a Greek pathological population. Plasma samples from AMI patients and healthy subjects (controls) were analyzed using TaqMan® MicroRNA assays. The concentration of both miRs was significantly elevated in AMI patients compared to healthy controls. Moreover, receiver-operating characteristic (ROC) curve analysis showed that miR-208b and miR-499 displayed similar properties with the established AMI biomarker cardiac troponin T (cTnT). We showed, for the first time, that these miRs could be used as AMI biomarkers in our population as well. Our data are in agreement with those of studies based on different population groups and further strengthen the observation that plasma levels of circulating miR-208b and miR-499 could serve as potential AMI biomarkers.

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Publisher

International Institute of Anticancer Research

Subject

Aged

/ Biomarkers

/ Blood & organ donations

/ Cardiomyocytes

/ Case-Control Studies

/ Circulating MicroRNA

/ Female