Asset Details
Do you wish to reserve the book?
Antimicrobial Multidrug Resistance and Mechanisms of Action: An Overview
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Antimicrobial Multidrug Resistance and Mechanisms of Action: An Overview
Do you wish to request the book?
Antimicrobial Multidrug Resistance and Mechanisms of Action: An Overview
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Antimicrobial Multidrug Resistance and Mechanisms of Action: An Overview
2025
Overview
Antimicrobial multidrug resistance is the ability of microorganisms to withstand the effects of several antimicrobial agents, presenting a major challenge to modern healthcare systems worldwide. Although considerable research has been conducted, the molecular and evolutionary mechanisms underlying resistance are still not completely understood. This review brings together current knowledge to explain how resistance originates, spreads, and persists in different pathogens. Microorganisms may show primary resistance, which arises naturally without prior exposure to drugs, or acquired resistance, which develops after contact with antimicrobial agents. Intrinsic resistance is related to structural or functional traits that are naturally present in specific species. Strains that are extensively resistant demonstrate survival against a wide range of important drugs, while clinical resistance becomes evident when standard treatments fail to control infections effectively. Pathogens employ several mechanisms, including enzymatic inactivation of drugs, modification of target sites, reduced drug uptake, and active efflux systems. Parasitic and fungal pathogens often rely on impaired drug transport and altered molecular targets, whereas viruses adopt multiple strategies to escape the activity of antiviral drugs. The appearance of highly resistant organisms such as methicillin‐resistant Staphylococcus aureus reflects the growing threat of so‐called superbugs. The rapid spread of resistance, driven by genetic mutations and horizontal gene transfer, highlights its ability to disseminate quickly within microbial populations. A clear understanding of these molecular processes is essential to guide the development of new therapeutic strategies, improve clinical management, and strengthen global efforts to control antimicrobial resistance.
Publisher
John Wiley & Sons, Inc,Wiley
Subject
/ Anti-Infective Agents - pharmacology
/ Anti-Infective Agents - therapeutic use
/ Bacteria
/ Drug Resistance, Multiple - drug effects
/ Drug Resistance, Multiple - genetics
/ Drug Resistance, Multiple, Bacterial - drug effects
/ Drug Resistance, Multiple, Bacterial - genetics
/ Drugs
/ Efflux
/ Humans
/ Methicillin-Resistant Staphylococcus aureus - drug effects
/ Methicillin-Resistant Staphylococcus aureus - genetics
/ Methicillin-Resistant Staphylococcus aureus - pathogenicity
/ Review
