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Reduced Immunoglobulin (Ig) G Response to Staphylococcus aureus in STAT3 Hyper-IgE Syndrome

by Hagl, Beate , Abel, Felicitas , Kahl, Barbara C. , Stentzel, Sebastian , Rack-Hoch, Anita , Renner, Ellen D. , Bröker, Barbara M.

in Adolescent / Adult / Antibodies, Bacterial - blood / BRIEF REPORTS / Child / Child, Preschool / Cystic fibrosis / Cystic Fibrosis - complications / Female / Gram-positive bacteria / Humans / Humoral immunity / Immune system / Immunity / Immunoglobulin E / Immunoglobulin G / Immunoglobulin G - blood / Immunoglobulins / Job Syndrome - complications / Job's syndrome / Male / Middle Aged / Patients / Staphylococcal Infections - immunology / Staphylococcus aureus - immunology / Stat3 protein / Young Adult

2017

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Reduced Immunoglobulin (Ig) G Response to Staphylococcus aureus in STAT3 Hyper-IgE Syndrome

by Hagl, Beate , Abel, Felicitas , Kahl, Barbara C. , Stentzel, Sebastian , Rack-Hoch, Anita , Renner, Ellen D. , Bröker, Barbara M.

2017

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Reduced Immunoglobulin (Ig) G Response to Staphylococcus aureus in STAT3 Hyper-IgE Syndrome

by Hagl, Beate , Abel, Felicitas , Kahl, Barbara C. , Stentzel, Sebastian , Rack-Hoch, Anita , Renner, Ellen D. , Bröker, Barbara M.

2017

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Journal Article

Reduced Immunoglobulin (Ig) G Response to Staphylococcus aureus in STAT3 Hyper-IgE Syndrome

Hagl, Beate,

Abel, Felicitas,

Kahl, Barbara C.,

Stentzel, Sebastian,

Rack-Hoch, Anita,

Renner, Ellen D.,

Bröker, Barbara M.

2017

Overview

STAT3 hyper-IgE syndrome (STAT3-HIES) patients presented with significantly lower Staphylococcus aureus-specific serum IgG compared to cystic fibrosis patients despite recurrent S. aureus infections. Immunoglobulin replacement therapy increased S. aureus-specific IgG in STAT3-HIES patients and attenuated the clinical course of disease suggesting a role of humoral immunity in S. aureus clearance.

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Publisher

Oxford University Press

Subject

Adolescent

/ Adult

/ Antibodies, Bacterial - blood

/ BRIEF REPORTS

/ Child

/ Child, Preschool

/ Cystic fibrosis