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Metallo‐Organic Complexes Containing Transition Metals; Synthetic Approaches and Pharmaceutical Aspects
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Metallo‐Organic Complexes Containing Transition Metals; Synthetic Approaches and Pharmaceutical Aspects
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Journal Article
Metallo‐Organic Complexes Containing Transition Metals; Synthetic Approaches and Pharmaceutical Aspects
2025
Overview
Coordination compounds offer a flexible framework for the thoughtful design of novel therapeutic‐metallodrugs because of the unique properties of metal ions, such as their ability to coordinate with a wide range of organic ligands, variable oxidation states, a wide range of geometries, and coordination numbers. The pharmaceutical potential of a metal ion and associated substances is validated by the prevalence of various disease states linked to a metal ion‘s excess or deficiency within the biological system. Researchers have sought more selective, efficacious metallodrugs that cause fewer adverse effects. Attempts have resulted in considering a large range of organic ligands, preferably polydentate ligands with demonstrated biological activity, and a large range of metals from the periodic table, primarily from the d‐block. In this review, we have outlined the key coordination complexes comprising N‐, O‐, and S‐donor ligands reported in the last six years to demonstrate the potential applications of these metallo‐organic complexes. The synthetic pathways of ligands, their complexes, and their potential for therapeutic applications are highlighted. Transition metal complexes are therapeutically more potent than their free ligands. The present review highlights the synthesis of coordination complexes comprising N‐, O‐, and S‐donor ligands and their pharmaceutical potential as antimicrobial, anticancer, enzyme inhibition, and antioxidant agents. Metallo‐organic complexes of Cu, Co, and Zn show high potency, paving the way for developing novel, affordable, and efficient treatments for various diseases.
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