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Serum alpha klotho levels in Parkinson’s Disease
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Journal Article
Serum alpha klotho levels in Parkinson’s Disease
2025
Overview
Purpose
Parkinson’s Disease (PD), a neurodegenerative disorder, is associated with substantial morbidity. α-Klotho, an anti-aging protein known for its neuroprotective properties, has gained attention. This study aims to assess serum levels of α-Klotho in PD patients.
Methods
This study is a cross-sectional case-control study. PD was diagnosed according to UK Parkinson Disease Society Brain Bank criteria. Serum α-Klotho level was measured using a commercially available enzyme-linked immunosorbent assay.
Results
Of the 314 participants in the study, 157 were patients with PD and 157 were controls. Lower levels of α-Klotho were observed in PD (0.85 nmol/L) in comparison to the controls (1.47 nmol/L,
p
< 0.001). α-Klotho levels were also significantly lower among PD patients with dementia compared to PD patients without dementia. In logistic regression analysis, α-Klotho (OR: 0.04,
p
< 0.001) demonstrated a significant relationship between PD. A significant correlation was identified between α-Klotho levels and Mini-Mental State Examination scores in PD patients. The sensitivity and the specifity of α-Klotho were 90% and 65% for predicting PD.
Conclusions
Our findings suggest that α-klotho could potentially serve as a biomarker. However additional studies are needed to confirm our findings.
Key points
Aim
This study aimed to investigate the potential association between α-Klotho, a protein implicated in longevity, and Parkinson’s Disease, the most prevalent motor system disorder.
Findings
Our findings revealed both an association between serum α-Klotho protein and Parkinson’s Disease and its potential value for diagnostic applications.
Message
This study demonstrates an association between α-Klotho protein levels and Parkinson’s Disease, suggesting its potential as a biomarker for Parkinson’s Disease diagnosis.
Publisher
Springer International Publishing,Springer Nature B.V
Subject
