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Does time of intraoperative exposure to the aerobiome increase microbial growth on inflatable penile prostheses?
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Does time of intraoperative exposure to the aerobiome increase microbial growth on inflatable penile prostheses?
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Journal Article
Does time of intraoperative exposure to the aerobiome increase microbial growth on inflatable penile prostheses?
2025
Overview
Inflatable penile prosthesis (IPP) implantation is a surgical approach for the management of erectile dysfunction (ED). A feared complication is IPP infection, and increased operative time is a risk factor for infection. Exposure of an IPP implant to ambient air in the operating room (OR aerobiome) is thought to contribute to risk of infection from increased operative time, but this is not well-supported. The objective of this study was to evaluate if exposure to the OR aerobiome increased microbial colonization of IPPs. This was an ex vivo study using an uncoated IPP, observing standard surgical sterility and OR conditions. A sterile swab was collected every 30 min for 3 h from each IPP component. Positive controls consisted of swabs exposed to unprepped scrotal skin during in-office vasectomies. All swabs underwent quantitative polymerase chain reaction (qPCR) and next generation sequencing (NGS). Bioinformatic processing was carried out and taxonomic assignment was performed. No microbial growth was detected on any component of the IPPs at any time point, while positive control swabs all detected various skin flora, including bacterial and fungal growth. These findings suggest that exposure to the OR aerobiome does not increase the risk of IPP microbial colonization, at least within a 3-hour period. Further in vivo studies are needed.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 45/23
/ 692/499
/ Bacteria - growth & development
/ Erectile Dysfunction - microbiology
/ Humans
/ Male
/ Medicine
/ Penile Implantation - adverse effects
/ Penile Implantation - methods
/ Penile Prosthesis - adverse effects
/ Penile Prosthesis - microbiology
/ Penis
/ Prosthesis-Related Infections - microbiology
/ rology
/ Urology
