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Brain Volume Changes in Patients with Acute Brain Dysfunction Due to Sepsis
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Brain Volume Changes in Patients with Acute Brain Dysfunction Due to Sepsis
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Journal Article
Brain Volume Changes in Patients with Acute Brain Dysfunction Due to Sepsis
2020
Overview
Background
Sepsis-induced brain dysfunction (SIBD) is often encountered in sepsis patients and is related to increased morbidity. No specific tests are available for SIBD, and neuroimaging findings are often normal. In this study, our aim was to analyze the diagnostic value of volumetric analysis of the brain structures and to find out its significance as a prognostic measure.
Methods
In this prospective observational study, brain magnetic resonance imaging (MRI) sections of 25 consecutively enrolled SIBD patients (17 with encephalopathy and 8 with coma) and 22 healthy controls underwent volumetric evaluation by an automated segmentation method.
Results
Ten SIBD patients had normal MRI, and 15 patients showed brain lesions or atrophy. The most prominent volume reduction was found in cerebral and cerebellar white matter, cerebral cortex, hippocampus, and amygdala, whereas deep gray matter regions and cerebellar cortex were relatively less affected. SIBD patients with normal MRI showed significantly reduced volumes in hippocampus and cerebral white matter. Caudate nuclei, putamen, and thalamus showed lower volume values in non-survivor SIBD patients, and left putamen and right thalamus showed a more pronounced volume reduction in coma patients.
Conclusions
Volumetric analysis of the brain appears to be a sensitive measure of volumetric changes in SIBD. Volume reduction in specific deep gray matter regions might be an indicator of unfavorable outcome.
Publisher
Springer US,Springer Nature B.V
Subject
/ Amygdala - diagnostic imaging
/ Atrophy
/ Bacteria
/ Caudate Nucleus - diagnostic imaging
/ Cerebellar Cortex - diagnostic imaging
/ Cerebellar Cortex - pathology
/ Cerebellum - diagnostic imaging
/ Cerebral Cortex - diagnostic imaging
/ Cerebral Infarction - diagnostic imaging
/ Coma
/ Female
/ Gray Matter - diagnostic imaging
/ Hippocampus - diagnostic imaging
/ Humans
/ Male
/ Medicine
/ Patients
/ Posterior Leukoencephalopathy Syndrome - diagnostic imaging
/ Putamen - diagnostic imaging
/ Sepsis
/ Sepsis-Associated Encephalopathy - diagnostic imaging
/ Sepsis-Associated Encephalopathy - etiology
/ Sepsis-Associated Encephalopathy - physiopathology
/ Thalamus - diagnostic imaging
