Journal Article

Cardiometabolic factors and risk of non-arteritic anterior ischemic optic neuropathy: a systematic review and meta-analysis

Kazantzis Dimitrios, Sergentanis, Theodoros N, Theodossiadis, Panagiotis G, Chatzirallis, Alexandros P, Psaltopoulou Theodora, Machairoudia Genovefa, Papageorgiou, Effie G, Chatziralli, Irini P, Theodossiadis, George P

2022

Overview

Abstract PurposeThe purpose of this systematic review and meta-analysis of the literature is to evaluate the association between cardiometabolic risk factors (hypertension, diabetes mellitus, hypercholesterolemia/dyslipidemia, HDL cholesterol, LDL cholesterol, lipoprotein(a), and triglycerides) and non-arteritic anterior ischemic optic neuropathy (NAION).MethodsPertinent publications were identified through a systematic search in PubMed and EMBASE databases, without language restrictions. The pooled odds ratios (OR) and standardized mean differences (SMD), with their 95% confidence intervals (95% CI) were estimated using random effects (DerSimonian Laird) models, as appropriate. A set of subgroup analyses and meta-regression analysis models were performed.ResultsTwenty-one studies (including 1560 patients with NAION and 2292 controls), examining the association between NAION and cardiometabolic risk factors, were eligible for the systematic review and meta-analysis. Hypertension (pooled OR = 1.50; 95% CI: 1.16–1.94), diabetes mellitus (pooled OR = 1.71; 95% CI: 1.33–2.21), and hypercholesterolemia/dyslipidemia (pooled OR = 2.00; 95% CI: 1.53–2.62) were associated with NAION. Among the components of dyslipidemia, higher serum triglycerides were associated with NAION, with a medium effect size (SMD =  + 0.58, 95% CI: + 0.12 to + 1.04), whereas synthesis of four studies reporting on HDL and LDL cholesterol did not reveal any significant associations. A significant association between NAION and higher serum lipoprotein(a) levels (pooled OR = 2.88; 95%CI: 1.01–8.21) was also noted.ConclusionsThis systematic review and meta-analysis found that NAION was associated with cardiometabolic factors, suggesting that vascular dysfunction may be implicated in the pathogenesis of the disease. Our findings may alert health care providers to try modifying these risk factors for NAION prevention.

• Publisher: Springer Nature B.V
• Subject: Cholesterol / Diabetes / Diabetes mellitus / Diabetic neuropathy / Dyslipidemia / Health care / High density lipoprotein / Hypercholesterolemia / Hypertension / Ischemia / Low density lipoprotein / Meta-analysis / Metabolic disorders / Ophthalmology / Optic neuropathy / Regression analysis / Risk factors / Systematic review / Triglycerides