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Acute lymphoblastic leukemia in children and SALL4 and BMI-1 gene expression
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Acute lymphoblastic leukemia in children and SALL4 and BMI-1 gene expression
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Journal Article
Acute lymphoblastic leukemia in children and SALL4 and BMI-1 gene expression
2023
Overview
Background
Sal-like protein 4 transcription factor (
SALL4
) and B cell-specific Moloney murine leukemia virus integration site 1 (
BMI-1
) gene were reported to cause treatment failure and relapse in several malignancies. We aimed to evaluate the prognostic value of
SALL4
and
BMI-1
in children with acute lymphoblastic leukemia (ALL).
Methods
This prospective cohort study was carried out on 60 children with ALL as the patient group and 60 age- and sex-matched children as the control group. We evaluated the expression pattern of both
SALL4
and
BMI-1
genes in the peripheral blood using real-time reverse transcriptase-polymerase chain reaction in children with ALL at initial diagnosis before chemotherapy. We followed up with the patient group for 2 years for relapse or death.
Results
Both
SALL4
and
BMI-1
were overexpressed in ALL children compared to the control group. Moreover, the expression of
SALL4
and
BMI-1
in patients with relapse was significantly higher than those with complete remission. The best cut-off of
SALL4
and
BMI-1
to predict relapse were >2.21 and 0.55 yielding sensitivity of 92.3% and 84.6%, respectively. Patients with overexpression of
SALL4
and
BMI-1
had significantly shorter overall and disease-free survival.
Conclusions
SALL4
and
BMI-1
could be useful prognostic markers in children with ALL to predict relapse.
Publisher
Nature Publishing Group US,Nature Publishing Group
